STEROID BIOSYNTHESIS BY SURVIVING TESTICULAR TUMOR TISSUE
نویسندگان
چکیده
منابع مشابه
Steroid biosynthesis by surviving testicular tumor tissue.
The appearance of gynecomastia and other feminizing symptoms in the male concomitant with the appearance of certain types of testicular tumors has long been noted (1). Therefore, the possibility has been suggested that these tumors produce excessive amounts of female sex hormones. The recent work of Goldzieher and Roberts (2) demonstrated that human testes contain small amounts (5.7 y per kilo ...
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Sulfate esters of steroid hormones had been considered to represent end products of steroid metabolism designed for excretion. Sulfation of steroids in vitro had been demonstrated with mammalian liver preparations, and it had been generally assumed that the liver was the major site of production of these compounds in man. Revision of this view became necessary with the demonstration that the st...
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The initial clinical, pathological, and hormonal investigation of a patient with testicular feminization syndrome is described. Incubation of gonadal tissue with various radioactive substrates, together with the isolation and identification of the resulting metabolites, was demonstrated a high capacity to synthesize testosterone. Two biosynthetic pathways were demonstrated, originating from pro...
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The treatment of rats with cis-platinum for 7 days caused a profound, and seemingly selective, decrease (70-80%) in the microsomal cytochrome P-450 levels in the testis. This decrease was accompanied by marked reductions (70-80%) in steroid 17 alpha-hydroxylase activity and in plasma testosterone concentration. The treatment of rats with human chorionic gonadotropin partially restored the cytoc...
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Kinetic studies of the cleavage of dehydroepiandrosterone-sulfate (i) and androstenediol-3-sulfate by a particulate enzyme preparation from a rat testicular microsomal fraction gave K m values of 2.04 x 10-6M for DHA-S and 0.935 x 10-6M for androstenediol-3-sulfate with identical Vma x values° Inhibition studies with equimolar concentrations of substrate and inhibitor demonstrated that 5~-andro...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)81423-0